I've lost track of how many software applications I've learned. When I have a need I typically go out, find a tool, and figure out how to make it work.
If I were stuck on a desert island, here's what I'd want in my toolbox:
Joomla!
Dreamweaver Flash Photoshop Acrobat Premiere
HTML CSS
ColdFusion PHP
MySQL
Apache
Windows XP/Vista
WordExcelPowerpointOutlookAccessVisioProject
Linux
Python FileZilla SUPER PuTTY CVS Eclipse SDK WinMerge